*Tid:* **19 mars 2012 kl 15.15-16.00.**
**Seminarierummet 3721**, Institutionen för
matematik, KTH, Lindstedts väg 25, plan 7.
Karta!
*Föredragshållare:*
**
Professor Yudi Pawitan,
Department of Medical Epidemiology
and Biostatistics,
Karolinska Institutet
**
**Titel:**
Searching for and assessing subtypes in a heterogeneous population
**Abstract**
Biological heterogeneity is common in many diseases, and it is often the source
of failure to get good prognostic models. In an analysis of lung cancer gene
expression data, we are investigating a clustering method to search for
molecular subtypes for which we can obtain better prognosis. In the process of
assessing whether a subgroup is interesting, we often find p-value distributions
with substantial shortage of small values. This turns out to be a common
occurrence in heterogeneous populations. Ignoring this effect will lead to
biased inference, where we would miss potential discoveries by overestimating
the false discovery rate. I will describe a model that explains the phenomenon
and show how to analyze the p-value distribution in order to get an unbiased
inference.
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